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In recent years, membrane technology has rapidly “brought” in the pharmaceutical industry

From September 13th to 15th, a remarkable "big show" took place at the Beijing International Exhibition Center, with membrane technology as its central theme. At the 2006 China International Film Industry Exhibition, organized by the China Petroleum and Chemical Industry Association and the China Film Industry Association, over 100 domestic and international film and technology companies showcased their latest innovations. The exhibition attracted a continuous flow of visitors eager to explore the future of pharmaceutical production. Reporters on-site observed several new membrane technologies and equipment specifically developed for drug manufacturing. Experts highlighted that, due to increasing demands for higher drug quality and cost reduction, membrane techniques such as ultrafiltration, pervaporation, and membrane distillation have become key players in the medical field. These technologies help solve complex issues in extraction, separation, concentration, and purification, significantly enhancing the overall efficiency and quality of pharmaceutical production. Ultrafiltration has made significant progress in recent years, particularly in addressing challenges like depyrogenation in injectable drugs. Traditional methods using activated carbon were labor-intensive and led to high losses. However, ultrafiltration membranes with molecular weight cut-offs can effectively remove pyrogens without damaging active ingredients. For instance, studies by Beijing University of Traditional Chinese Medicine showed that ultrafiltration produced higher baicalin content and better clarity in Qingkailing injection compared to traditional methods. At the event, Associate Professor Yan Yanbin from Beijing Forestry University shared his insights. He emphasized that ultrafiltration is ideal for removing pyrogens from injections containing large molecules like flavonoids and alkaloids. His research also showed that ultrafiltration improved the stability and clarity of several herbal injections, reducing sedimentation and preserving active components. In addition, ultrafiltration has been successfully applied in antibiotic processing, such as penicillin and cephalosporins, leading to higher yields, lower costs, and reduced environmental impact. It also plays a crucial role in vitamin C production, where it replaces energy-intensive heat precipitation methods. Pervaporation, another advanced membrane technology, is gaining popularity for its energy-saving advantages. It separates liquid mixtures based on differences in solubility and diffusion. Companies like Harbin Pharmaceutical and Shenyang Dongrui have implemented this technology for ethanol dehydration and solvent recovery, achieving economic benefits and operational efficiency. Membrane distillation, which uses hydrophobic membranes to separate solutions based on temperature differences, is particularly useful for heat-sensitive substances. It allows for low-temperature concentration and high-purity separation, making it ideal for applications in traditional Chinese medicine and pharmaceuticals. Overall, membrane technologies are transforming the pharmaceutical industry, offering more efficient, sustainable, and high-quality solutions for drug production. Their growing adoption highlights their potential to revolutionize the sector in the coming years.

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